This product supplies bioactive forms of four essential B-vitamins together with betaine (also known as trimethylglycine or TMG) to synergistically support methylation processes and normal homocysteine metabolism. The body’s methylation process is vital for formation of essential cell components such as proteins, nucleic acids found in DNA and RNA, and phospholipids that form nerve cell membranes. By transferring methyl groups (three hydrogen atoms bonded to a carbon atom, known as CH3) from one molecule to another, methylation turns on genes, activates enzymes, drives detoxification reactions, influences hormone secretion, and helps maintain normal metabolism of homocysteine, a potentially harmful amino acid metabolite. Unfortunately, poor nutrition, oxidative stress, infections, metabolic defects, and various other factors can impair methylation processes throughout the body. To nutritionally support optimal methylation capacity, this product supplies folate, vitamin B12, B6, B2, and betaine in amounts and forms that are efficiently utilized and well-tolerated by the body.
Supports methylation processes: Most methylation reactions involve the molecule S-adenosylmethionine (SAM) as a methyl group donor. Thus, supporting the formation of SAM can be a viable approach to supporting methylation processes. Folate and vitamin B12 support methylation capacity, as they are essential players in the pathway that produces SAM. Vitamin B2 and betaine also play various different roles to help ensure adequate SAM production, whereas vitamin B6 contributes to methylation processes by facilitating the formation of methyl groups. For optimal nutrient absorption and utilization, this product provides biologically active forms of folate (as Metafolin®** L-5-methyltetrahydrofolate) and vitamin B12 (as methylcobalamin). These forms are already fully “active” and readily usable, as they do not require further metabolism in the body. Active forms of vitamin B2 (as riboflavin 5’-phosphate) and vitamin B6 (as pyridoxal 5’ phosphate) are also provided for highest absorption and bioavailability.
Helps maintain normal homocysteine metabolism: Optimizing homocysteine metabolism can play an important role in maintaining healthy cardiovascular and cognitive functions. Homocysteine can either be converted to the amino acid cysteine through a series of vitamin B6-dependent reactions or converted to the essential amino acid methionine through a methylation reaction involving folate and vitamin B12. Some individuals are more susceptible to homocysteine accumulation as they are unable to fully convert common forms of folate (such as oxidized folic acid) and B12 (such as cyanocobalamin) into their active forms. In contrast, providing folate and vitamin B12 in their active, methylated forms provides a reliable approach to supporting homocysteine metabolism. Betaine also assists homocysteine regulation through an alternative pathway in which it supplies important methyl groups that allow homocysteine to be safely converted to methionine.
This dietary supplement can be taken by individuals who wish to nutritionally support methylation and homocysteine metabolism. This product is free of the following common allergens: milk/casein, eggs, fish, shellfish, tree nuts, peanuts, wheat/gluten, corn, yeast, and soybeans. Contains no artificial colors, flavors, or preservatives.